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Generating Excel 97+ files with Python 2.4+ (need decorators), importing Excel 95+ files, support for UNICODE in Excel files, using variety of formatting features and printing options, Excel files and OLE2 compound files dumper. No need in Windows/COM
PythonOffice is a Python API for the Ms XML (Excel) Spreadsheet format. It allows you to read and write Excel XML documents from within the Python programming language. In future, support for other formats is planned, including OOo, Ms Open Xml.
pyXLWriter is a Python library for generating Excel compatible spreadsheets. It's a port of John McNamara's Perl Spreadsheet::WriteExcel 1.0 module (see http://www.cpan.org) to Python. Requires Python 2.1+. [Project was stopped]