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AudiOpen is a framework and GUI for audio synthesis, with the goal of developing an environment where obtaining the waveform you want is very intuitive by taking a very systematic/mathematical approach to defining audio and supporting Python scripts.
Replacement for the Java Media Framework (JMF), allowing you to transport not only audio and video. In extention a modular software synthesizer designer/sequencer sharing local hardware over the internet.
SOMba is a Qt based program that allows multiple dancers to create a collaborative sonic space, using audio clips organized by a Self-Organizing Map. It uses the Marsyas framework for audio feature extraction and playback.