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Nixstaller is an Open Source project with the goal to create user friendly and flexible installers that work on various UNIX like systems. Some of its features are: small size overhead, large compatibility, Lua scripting and few dependencies.
ProgPorts is an administrative and easy user interface to hundreds of proteomics, molecular dynamics, and protein crystallography programs. It is a hybrid of the prog/setup system, developed at Johns Hopkins University, and GNU-Darwin ports system.