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wxGlade is a GUI designer written in Python with the popular GUI toolkit wxPython, that helps you create wxWidgets/wxPython user interfaces. It can generate Python, C++, Perl, Lisp and XRC (wxWidgets' XML resources) code.
Ophidian is a Python module created to easily develop wxPython user interfaces. Ophidian provides wrapper classes to transparently load XRC resources and access the user controls inside them, with a minimum of coding effort.
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General resource handling module for Python.
It is developed with wxPython GUI resources in mind, but unlike the XRC resource system, this is an universal solution, applicable to anything you can call a resource and much more flexible.