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The DPA Toolset allows defining subsets of an XML Schema (profiles), definition of concrete profile documents, can monitor the exchange of those documents as SOAP web services, and emulate SOAP endpoints if needed. Cable-industry specific license.
HIEOS is an open source implementation of, primarily server-side, Integrating the Healthcare Enterprise (IHE) Integration Profiles including Cross Enterprise Document Sharing (XDS.b) and Cross Community Access (XCA) integration profiles.
MOLGENIS can be used to generate databases for life science experiments (micrroarray, mass spectrometry, genomics) having a web user interface, csv exchange format, and programmatic interfaces (web services, rest, and r-project). See NatRevGen 8.