Search Results for "aspect"

...Algorithm implementation for population pharmacokinetic analysis: The current project describes the marriage between PBPK modeling and population-based statistical analysis. The latter is necessary for parameter estimation when individual-level data is available. A critical aspect of this coupling is the implementation of an algorithm that would allow the performance of population-based statistical analysis. Although novelty is encouraged in regards to the algorithm, proposals could entertain approaches such as: a. Implementing the non-linear mixed effects theory, b. Maximum log-likelihood algorithms (stiff, non-stiff Ordinary Differential Equation solving methods with linearization)