Selenium-python is great for web automation. Helium makes it easier to use. Helium ships with its own copies of ChromeDriver and geckodriver so you don't need to download and put them on your PATH. Unlike Selenium, Helium lets you interact with elements inside nested iFrames, without having to first "switch to" the iFrame. Helium notices when popups open or close and focuses / defocuses them like a user would.