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Kura is a complete, professional system for the handling of linguistic data, especially fieldwork data from small-corpus languages. It allows users to enter texts in any language and analyze those texts
Tk-based standalone graphing system and extensible graphing library with a huge range of 2d modes (maybe 3d soon?) written in Python (Python/Tk are 100% cross platform)
SeqFreed is a bioinformatics desktop. It provides efficient access to sequence data and gene features, a customizable command line interface to locally installed bioinformatic tools and flexible display of either text or images in different page modes.
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Yabman is a tool for managing bibliographic references. Its key features are a quality user interface, a carefully designed data model, and sophisticated three-state hierarchical reference labeling. It is currently usable but in a pre-alpha stage.
cl-calc aims to be a simple command line calculator. It can handle precedence unlike a lot of graphical calculators. cl-calc is written in Python and requires PLY (Python-Lex-Yacc).
The Liberlab project aimed in 2004-2006 to promote scientific experimentation through the creation and use of a digital lab at a very low cost (15 €/$). Don't link to old site (URL squatting). See archive (http://sites.google.com/site/liberlabsite)
ProcessViewBrowser & ProcessViewServer represent an OpenSource attempt to industrial process visualization. It is based on Qt and is very portable. (Now also available as commercial software)
AVPython embeds the Python programming language within ArcView GIS 3.x. This project will also encompass efforts to build a similar bridge between Python and ArcObjects. An integrated, redistributable Python / PyWin32 setup wizard is also published here.
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GerbTool is a set of tools for modifying gerber and excellon drill files. GerbTool can be used to tile multiple gerber files as a single job, and can be run interactively or in batch mode.
clusterviz allows to cluster three-dimensional data. The clustering process is visualized using OpenGL. As clustering algorithms the family of k-means algorithms is implemented, including mixture models.
Banyan is an enterprise class, web based, information management system that helps people work collaboratively to solve complex problems. Banyan increases project performance and reduces risk through the power of collaborative clear thinking.
RStatServer is a system for quickly developing and deploying web applications that integrate statistical computations and graphics. It is built using the Zope web application develeopment system and the open-source statistical data analysis environment R
NGmp is a C# C++ Java Python VB.NET etc. etc. binding of GMP and MPFR multi-precision number libraries. With support of Microsoft .NET or Novell Mono runtime NGmp will run on mutliple platforms. It is faster than other libraries available on .NET or Mono
Open source development of a tool for the astronomy community to interact with the GRB Coordinates Network (GCN) broadcast of real-time gamma-ray burst (GRB) and X-ray Flash (XRF) information. Support for satellite packets: HETE-2, Integral, Swift
A configurable knowledge management framework. It works out of the box, but it's meant mainly as a framework to build complex information retrieval and analysis systems. The 3 major components: Crawler, Analyzer and Indexer can also be used separately.