Source code from the Research Institute for Signals, Systems and Computational Intelligence http://fich.unl.edu.ar/sinc
Bioinformatics Perl extension for the analysis of antibody variable domain repertoires. Suitable for mammalian repertoire sequences obtained either by Sanger or 454 sequencing. Methods published in Glanville, Zhai, Berka et al, PNAS 2009.
FOCIS finds features for functional follow-up
FOCIS (Feature Overlapper for Chromosomal Interval Subsets) performs an interval-based screen of a database of genomic features – ChIP-seq peaks, motif matches, and others – for overlap enrichment at a specific subset of genomic regions relative to a dataset-matched background. It was recently used to discover a novel enhancer that mediates drug resistance in melanoma.
ChIPOTle is a peak-finding algorithm used to analyze ChIP-chip microarray data
RIPCAL is a bioinformatics tool for the analysis of repeat-induced point mutation (RIP) of fungi. If you publish work using RIPCAL please cite: Hane & Oliver, BMC Bioinformatics 2008, 9:478
Selects SNPs and samples with known genotypes for microarray design
Program apply linear programming to minimize the number of microarrays and hybridization experiments that need to be undertaken in order to cover most of the predicted expressed SNPs.Dependencies:. 1) mampl.exe must be in system PATH 2) CPLEX 12.2 must be installed. cplexamp.exe must be in system PATH mampl.exe can be obtained from any program containing AMPL. I obtained AMPL from trial version of MOSEK at http://www.mosek.com/. CPLEX 12.0 can be obtained from http://www-01.ibm.com/software/integration/optimization/cplex-optimizer/. A free acadamic license can be obtained by filling out IBM academic initiative application.
identification of sequence variant associated with splicing event
To generate correct mature mRNAs, the exons must be identified and joined together precisely and efficiently by RNA splicing mechanism. It is to be noted that about one third or a half of all disease-causing mutations effect RNA splicing. However, there is little bioinformatics tools to directly identify sequence variants associated with splicing events (SVASE) based on RNA-seq data. We developed ISVASE, a simple and convenient tool for identifying SVASE directly using RNA-seq data. Comparing with the existing software PVAAS, our method has several advantages such as stringent rule-depended filters and statistical filters in each step, detection sequence variants for known splicing events, identification sequence variants in two parts of splicing (junction) separately, detection junction shift events if providing known splicing annotation, evaluating splicing signal, comparing with known DNA mutation and/or RNA editing data, and short running time.
A header file (cexcept.h) that provides Try/Throw/Catch macros similar to those available in C++ for error handling.
HBAT(Hydrogen Bond Analysis Tool) is a tool to automate the analysis of hydrogen bonds present in a PDB Structure file. Other related tools available from HBAT Project are PDIA(Post Docking Interaction Analysis) and HBNG(Hydrogen Bond Network Graph).
This software is a Perl Catalyst based electronic lab notebook (ELN) aiming for small biologic laboratories, that have no funding to invest into a closed source ELN.
A tool to streamline high density genetic linkage group constrcution
easy Primer prediction from Alignments and Consensus sequences
Primer prediction from alignments and consensus sequences. easyPAC applies all standard quality tests to degenerate primer and primer pairs and optionally maps all primer candidates to an arbitrary number of reference files like repeat databases or genomes to ensure target specifity.
PDFgetN is a program to process total scattering data obtained on neutron time-of-flight powder diffractometers and to obtain the atomic pair distribution function (PDF).
Detecting low-level mutations by utilizing the re-sequencing error profile of the data
HOPPscore is a simple application for evaluating the structural quality of theoretical or experimental protein structures. Protein are evaluated by comparing structure fragments to a reference dictionary of fragments from high resolution structures.
First automated tool for classification of transposable elements in eukaryotic organisms.
Reference based genome assembly and annotation for new genome
This program can assemble and/or annotate genome for new genome and known genome upgrade using sequence alignment file (SAM or BAM format), sequence variant file (VCF format or five coloum table (tab-delimited, including chromosome, position, id, reference allele and alternative allele)) or new genome sequence file (FASTA format) based on reference genome sequence file (FASTA format) and annotation file (TBL, GTF, GFF, GFF3 or BED format).
The OpenGEREA is a open enrichment analysis framework for gene expression regulation data analysis.
A.S.H. uses empirical correlations to generate scale-free network representations of protein relationships. These graphs are used to generated sub-networks and cliques which identify protein families and homologies.
Biosysplus is a software which use to generate ordinary differential equations for large scale molecular network. User just only need to provide some key reaction step and rate constant.
Blast Explorer facilitates Blast results exploration
Simulate the structural and copy number consequences of BFB
BFBsimulator simulates the structural and copy number consequences of breakage fusion bridge (BFB) cycles in silico. Hundreds of aCGH profiles of many different tumour types are now freely available and many of these newly surveyed genomes contain amplified oncogenes. The most commonly cited explanation for the processes underlying gene amplification is the the repeated fusion and breakage of chromosomes following the loss of a telomere. However, this proposition has never been fully investigated. Using BFBsimulator, we can ask: i) Can the complex patterns of amplification within cancer genomes really be generated by BFB cycles? ii) What visible effect might BFB cycles have on tumour copy number profiles? iii) Is there a specific copy number ‘signature’ of evolution though breakage fusion bridge cycles? iv) What is the prevalence of BFB cycling across different cancers?
Biological sequence analysis module used in generating CG clusters. Useful for basic sequence manipulations, regular expression based searches, and base compositional analysis.
CNV-WebStore is an integrated platform to analyse, store, visualise and interpret CopyNumber Variation data. Analysis is supported for Illumina data, all CNV-reports and raw data can be imported after third-party analysis. Contact system admin at http://cnv-webstore.uantwerpen.be for installation scripts
Calculator for (La)TeX Using (La)TeX language (mathematics environment only) for calculations by means of python, bc, maxima, octave or/and similar programs.