Chloe - a chatterbot with charisma. Learns from experience, and speaks any language you teach her. Perhaps even useful, but surely entertaining.
pyDATR is an implementation of the DATR language written in Python and usable as Python library. It provides a means for persistence and some extensability with Python functions.
Verbti - Email client for the blind
Jester is a gesture / stroke recognition framework for Python, written in Python.