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RTS2 is project to create an open source environment for control of a fully autonomous observatory. It is running about dozen fully autonomous observatories. Its modular design allow easily addition of new devices (to already huge supported HW list).
mod_openopc is a full featured implementation of the OpenOPC library for Python. It is cross platform compatible (full Python 2.5 and up). We used to recommend running it on a POSIX platform (Unix / Linux), but thanks to modest efforts since 2014, performance in Windows OS environments is excellent.
syphon is an extension for mod_openopc, to monitor telnet devices (serial devices) that sit on Serial -to- Ethernet bridges (such as barcode scanners) and export parsed data to an OPC compliant device (such as a PLC).