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RTS2 is project to create an open source environment for control of a fully autonomous observatory. It is running about dozen fully autonomous observatories. Its modular design allow easily addition of new devices (to already huge supported HW list).
An open-source program to control a custom-built piece of hardware called an "Olfactometer" that is developed at Cold Spring Harbor Labs. Chances are this software is only useful to people that have this hardware, but we are making it open-source.