A very Flexible and Plugin-able Test Automation Engine. It fully supports the Standardized Test Tool Interfaces as described in http://www.testtoolinterfaces.com/
TSL-TGE -- Test Specification Language-Test Generation Engine
Specify independent and dependent factors in an XML file, TSL. Then TGE makes substitutions of generated combinations into a template file. For use in Factorial Test Design.
AFTER is a configurable test engine written in Ruby. Libraries can be added to facilitate testing against any application type. It also allows for test scripts to be written in any format provided there is an associated script reader for that format.