elspy is an extension to the Exim MTA that allows Exim users to supply a local_scan() function written in Python instead of C. (Exim's local_scan() API lets sysadmins supply site-specific code for approving/rejecting email messages at SMTP time.)
PyEximon is a GNOME monitor/manager for the popular MTA, Exim. It includes real-time status graphs and log updates, colored log browsing, hierarchial message lists, as well as a graphical interface to common message functions.