The Ren'Py Visual Novel Engine
A game engine powered by python and panda3d
3D Engine with Blender Integration
A retro game engine for Python
Lutris desktop client in Python
Open source clone of the Age of Empires II engine
Easy to use Python library for creating 2D arcade games
GemRB is a portable open-source implementation of the Infinity Engine
An Open Source package that allows video game creators
TGMC: TerraGov Marine Corps, a SS13 mod
Arianne is an engine to develop multiplayer online games like Stendhal
Chess Stats is a slightly different way to analyze your chess games.
Vivid3D is a C++ IDE/3D engine, with python scripting.
An Arch Linux OS with 20+ custom GUI utilities & MLP theme customizer.
GameServer is a sophisticated, game server designed for online games
PyCAPGE - Python Classic Adventure Point and Click Game Engine
A frontend for GnGeo emulator written purely in Python
Pycraft is an open-source, OpenGL based game made in Python
A game engine for console based text games
The AWS GameKit Plugin for Unreal
DOOM / Heretic / Hexen source port with enhanced graphics and UI
ZED OS the clone of Windows XP