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Lwazi is a robust telephony platform aiming to facilitate speedy development of experimental applications without sacrificing power by combining Asterisk with the MobilIVR Python interface bundled into a single build with a unified control interface.
pyComPic is a GUI (Graphical UserInterface) for picprog, sdcc and gpasm written in Python. It uses pyGTK and GTK2 for the interface. It's a good choice if you want to avoid the command line. It works with all PIC programmers supported by picprog
ColladaCGF enables exporting 3D models into Crysis, using Crytek's resource compiler and Blender/Maya's Collada exporters. Import is partly supported as well, via the Python File Format Interface.
An easy to use graphical interface for configuring user settings for the Linux wacom drivers (http://linuxwacom.sourceforge.net/) - Note the author no longer has much time to work on wacom-config anymore so this project is only going to receive critical fixes (if that) going forward, It's suggested you look at alternative tools; which now have most of the features wacom-config lists (such as the kde wacom config tool - https://projects.kde.org/projects/extragear/base/wacomtablet)
jltk is a library for quickly creating GUIs, specifically for scientific applications, using Python. It is based on wxPython, and integrates plotting using matplotlib.
Use python to parse privoxy log in clf format and refer to wot ratings of the site and then dump the data in a sqlite database for statistics generation later.
yalimon (Yet another linux monitoring tool) is a python script that runs as a cron job, gathers data from several commands, stores it in a database and then creates graphs out of it. A web interface is used to view the images and to manage the module
Kmnr Radio Automation Program is a python program for automating a radio station by playing different shows, id's, and programming. Controlled through the parrallell port and feature a web interface showing history as well as "show" selection.
Blogging with reStructuredText. Use the simplicity of text to create, edit and delete posts and pages from a Wordpress blog using XMLRPC. Written in Python.
VIPS is an image processing suite designed for extremely large images and colorimetry. It consists of a powerful re-usable library and a graphical userinterface. http://www.vips.ecs.soton.ac.uk
The SBS1 Explorer application features a nice GUI allowing a variety of queries to any SBS-1 flights database without having to install the BaseStation software. Simply get a database file (usually BaseStation.sqb) and open it in SBS1 Explorer.
The X-Extensions for Python are a set of extension modules written in C and Python which provide access to various
standard X libraries to Python programs. The X libraries that are thus made accessible include Xt, Xaw, Xm and more.
Use zpu to upload pictures to a zenphoto gallery. Comes in handy when you have to upload a large amount of pictures, where the web interface is too slow.
FillWorks is python based standalone scientific tool for cut and fill bidimensional studies over terrain profiles. You'll be able to plan a train or road line and get the visual output on it. Complete, with user guide.
Project smat is mainly oriented on OpenSolaris and Linux : extend-able and easy to use text-mode administration utility written in Python/Curses. The Main purpose of the utility is to educate users by reviewing generated commands before execution.
Software Defined Radio Transceiver project is written in Python while using GNU Radio and USRP. The goal is to create a software HF transceiver with various modes. Go here for more info: http://apps.sourceforge.net/mediawiki/sdr/index.php?title=Main_Page