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Gnupylot is a GUI for gnuplot (the widely used multi-OS plotting utility). It's written in Python using PyQt4 libraries. With Gnupylot you can save your plots (even the datasets). It's still in Alpha stage.
The xVector Engine is a cross-platform 2D MMORPG engine written in Python. It will be a full-featured MMORPG engine allowing rapid game development without any programming knowledge, while still being easily extended with a Python scripting API.
Pycontrol lets you control a PLC using libnodave by simply providing CSV files describing the process values read from the PLC. Pycontrol will create a GUI from the CSV files.
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DICOM Tag Slayer lets you view, modify, export and find differences in DICOM-format files. Program is multiplatform, written in Python+PyQT4+PyDICOM gives you both GUI and CLI for easier script integration.
Convserver is a threaded XML-RPC webserver that converts files into various formats remotely. Convserver is not meant as a end-user tool but as middleware facilitating other applications like web applications, mobile apps and traditional GUI tools.
the python sudoku solver was done as a first year engineering project, it is programmed in python and it allows the user to enter in an unsolved sudoku .txt file which it then solves and presents the solved sudoku to the user in a user friendly gui.
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Distributed Parallel Programming for Python! This package builds on traditional Python by enabling users to write distributed, parallel programs based on MPI message passing primitives. General python objects can be messaged between processors. Ru
This simple project is a Nautilus extension to easily create new files. Practically, it is a Gtk GUI made in Python which enables you to create new files setting the initial content and permissions at a time.
Patch file shows difference in files in whole lines. Sometimes those lines are very similar, only one or two words changed. This script compares changed lines by characters and highlights actual differences in them - very helpful with long lines.
AudiOpen is a framework and GUI for audio synthesis, with the goal of developing an environment where obtaining the waveform you want is very intuitive by taking a very systematic/mathematical approach to defining audio and supporting Python scripts.
A modern secure, robust, multithreaded, exception aware, internationalisable, portable GUI toolkit library designed for mission-critical work in C++ and Python forked from the FOX library. Replicates the Qt API in many places.
Python fitting assistant is a fitting tool for eve online written in python. It is comparable to EFT. We can usualy be contacted via IRC on freenode (irc.freenode.org) in the #pyfa channel.
A library, GUI and sample cli script for managing Data Robotics storage units on Linux. (http://www.drobo.com)
There is a library, Drobo.py, which implements the ioctl interface defined in the published specs and code samples.
DTMF detector library and/or application that reads in the specified audio file and returns/outputs whether DTMF detected and/or list of detected digits. May have GUI and command line interfaces.
Snidget is a python program which tracks your financial information, in particular your expenses and income. The user adds each transaction on their accounts and snidget can provide reports about how much you're spending. Includes both CLI and GUI.