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PythonOffice is a Python API for the Ms XML (Excel) Spreadsheet format. It allows you to read and write Excel XML documents from within the Python programming language. In future, support for other formats is planned, including OOo, Ms Open Xml.
pyXLReader is a multiplatform Python library for reading Excel compatible spreadsheets (.xls). Based on JExcelApi by Andy Khan (http://www.andykhan.com).
pyXLWriter is a Python library for generating Excel compatible spreadsheets. It's a port of John McNamara's Perl Spreadsheet::WriteExcel 1.0 module (see http://www.cpan.org) to Python. Requires Python 2.1+. [Project was stopped]