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BPManager allows a closed network of users to manage tasks through messaging. In some ways it's similar to work-flow management software but tasks are managed in a way that resembles an e-mail application. Requests can be filed, delegated, completed BPM
fbreportz is a utility which accesses a FogBugz server via it's XML API in order to produce plots of various project metrics (FogBugz is a bug tracking product from Fog Creek software).
A laboratory information management system (LIMS) geared towards academic research groups in the life sciences. Written in Python and using the Django framework, you run this software on your own server.