AquaTerm is a Mac OS X grahics renderer. It allows command line applications written in ObjC, C, FORTRAN, Lisp, Perl or Python to display vector graphics, text and images using a simple API. Adapters for gnuplot, PGPLOT, and PLplot exists as well.
VocalEasel is a simple lead sheet editor and music rehearsal tool designed for the needs of Jazz vocalists, using LilyPond to produce printable lead sheets and MMA (Musical Midi Accompaniment) to produce MIDI accompaniments.
The Open Descent Foundation (ODF) is a community for developers, who want to help to create open source programs, tools, etc. for the famous games Descent1, -2 or -3. Everyone can join the ODF if he accepts the idea of writing open source programs.
HDRFlow is a framework to process high-dynamic range (HDR) and RAW images. It's written in C++, and is both cross-platform and hardware accelerated on modern GPUs.
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QuickDicom is an easy to use dicom medical imaging package for Mac OSX, providing QuickLook, Spotlight, Quartz Composer, Window/Level and a dicom file analyzer. Also included is the iiDicom Framework for image/dictionary usage in Objective C and Python.
A modular audio programming language, designed to write applications quickly. Its main goal is real time audio processing, but it should be used for any kind of development.