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See https://github.com/sitefusion
SiteFusion is a server-based development environment. Applications are written in PHP and work through a thin XUL client. SiteFusion applications look and behave like native system applications but run on a server generating JavaScript commands.
Developed by the manteiner Klederson Bueno, phpBurn is a MVC FRAMEWORK for PHP usage, initialy born as an ORM like hibernate and Nhibernate it allows you to create more and faster using OO concepts and patterns with a log of time gain.
SilverStripe is a Web Framework and Content Management System. It differs from many of the better known CMSes in that it uses fully object oriented code, has native Ajax support, and allows you to very cleanly customize the system to suit your needs.
The xWire framework is a toolkit used to build Java web applications, but is flexible enough for other uses. It is ideal for building AJAX apps and consists of both client and server components, each of which can be used independently of the other.