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Aurora Application Server is a new Python Web Application Server and Framework. The main goal of the project is to provide the developer with a complete set of tools to speed up the application development process. See project wiki for more information.
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CrUX is a collection of code writing utilities for developing XML based applications. The project is written in Python in an effort to be portable and cross platform compatible.
The Mandragora World Engine is a C++/Python engine which allows the easy creation of programs, including applications, simulations, and games. Able to load and run specific program modules. Will handle objects, graphics, sound, physics, GUI, and even AI.
Longenis is a simple, powerful object-oriented scripting language incoporating elements of Python, Tcl, Java, and Lua. It is designed to be light, clean, elegant, and cross-platform.
TurboGears 2 is a web framework, but unlike some of its competitors, it's not a monolithic unit, it's a collection of libraries, WSGI components, and web development tools that works well together and is configured to provide a great out of the box.
The PyQt4D (Python Qt for Designer) is an Open Source Project making Qt Designer full-featured RAD (Rapid Application Development) tool to develop data-aware two- or multi-tier applications using Python language and Qt library.