ACDK - Artefaktur Component Development Kit - is a platform independent C++-framework similar to Java or C#/.NET for generating distributed and scriptable components and applications.
FreeGee is an integrated application framework for Python and C++. Included modules are: Python (scripting), PostgreSQL (database), wxWidgets/wxWindows (GUI), GnuPG (crypto), omniORB (OO middleware), Apache (Web), and other fine tools (see Home Page).
Doulos is a set of tools for rapidly developing n-tier distributed applications, with a framework for writing business methods, a protocol for accessing those methods, and frameworks for creating web and native user interfaces that utilize the methods.
Language-independent interfaces like DOM, SAX and XSLT are not particularly "Pythonic". Several tools are contained in this
"XML2Python Interfaces" project that provide more natural ways of translating between XML and Python objects.