Two player Table Tennis video game made usign Python's PyGame library.
PyGame module inspired video game, "Pong" written exclusively in Python, is a great way to present the utmost capabilities and potentiality of the programming language.
MMBN Online is an open-source, cross-platform MegaMan Battle Network battle simulator. It is written in the Python language, using Pyglet as a library.
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Extirpation is a small Python (http://www.python.org) game in early development that uses the wxPython (http://www.wxpython.org/) library. It is a turn based strategy game with robots and very basic graphics. Check the SVN for the best version.