Gnupylot is a GUI for gnuplot (the widely used multi-OS plotting utility). It's written in Python using PyQt4 libraries. With Gnupylot you can save your plots (even the datasets). It's still in Alpha stage.
Whyteboard is a painting whiteboard application for Linux and Windows, that allows the annotation of PDF and PostScript documents, and image files with common drawing tools.
The OpynWorship project seeks to create a useful, free-and-open-source, multilingual, and cross-platform program written in python for churches or really anyone that needs presentation software to queue up various media for seamless presentation.
Transana is a cross-platform tool for the transcription and qualitative analysis of audio and video data. It also provides the ability to identify and organize analytically interesting portions of videos, as well as attach keywords to those video clips.
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A cross-platform aplication to explore online free maps (OpenStreetMap). Build with python and pygame, full immersive environnement. Actually only source code, require pygame.
Snappy is a fast, easy to use, crossplatform screenshot/screencast application currently being written in Python. It will integrate with many services, allowing the user to quickly upload to YouTube/ImageShack/FTP/etc.
The athenaCL system is a cross-platform, open-source, object-oriented composition tool written in Python. Note: Development of Version 2 has moved to Google Code: http://code.google.com/p/athenacl/
HDRFlow is a framework to process high-dynamic range (HDR) and RAW images. It's written in C++, and is both cross-platform and hardware accelerated on modern GPUs.
OpenVIP (Open Video Processor) is a cross-platform, highly modular non-linear video editor and video processing library. It is available for Windows and Unix.
TuneConnect is a complete software-based iTunes remote control solution. Utilizing the powerful Tunage API, TuneConnect is capable of cross-platform control, and is ideal for any usage environment.
Python module using FontTools to query TTF font files for metadata and font outlines in a cross-platform manner. Includes support for scanning for installed system TTF files on common platforms.
pyGLFW is a set of python bindings to the successful cross-platform GLFW. It is intended as a powerful and lightweight alternative to pygame for python OpenGL application development.
Nusq is a cross-platform modular music sequencer, intended to be sufficiently expandable, flexible and configurable for the technically-minded musician while still being accessible to the rest of us.
Spineless is a generic cross-platform 3D game engine implemented in Python. Focus is on flexibility, clean design and ease of use, not pure speed or bleeding edge graphics.
MayaVi is a free, crossplatform, easy to use scientific data visualizer. It provides a GUI to ease the visualization process, is written in Python and uses the Visualization Toolkit (VTK) for the graphics.
Noozy is an advance digital cross-platform music player mastered by Noozxoide sound processor its own. On this new baked 3ZS version many improved from the previous...
Plasmatic is a crossplatform multimedia delivery and playback system. While designed primarily for digital signage applications, its flexibility allows for any number of uses.
...Can overlay images, xy-data, and mathematical functions. Function parameters can be tuned with sliders; functions can also be automatically fitted to data. Written in Python, cross-platform, but currently broken
The Pretty Poly 3D Modeller is a project to produce a free, powerful 3D modeller for Linux primarily, but built for cross-platform from the start. Since Pretty Poly loads and saves in many different 3D file formats, it is also a useful model format conver
BLIX is a cross-platform set of Python extension modules and Python scripts for Blender (www.blender.org). These scripts add camera calibration, 3D reconstruction and rigid body orientation to Blender.
Xgdk is a Cross-Platform Game Development toolKit. Its purpose is to provide a set of easy-to-use and extendable libraries for rapid development of 3d interactive applications such as videogames, demos and prototypes.
xtopdf: Tools to convert other formats (x) to PDF; x as in math. - solve for x :-)
Currently x == {.txt, .DBF}. Others to follow.
Benefits: all those of PDF (better cross-platform viewing/printing, read-only, etc.)
PyDemeter is a Python wrapper for the Demeter terrain engine, a cross-platform terrain rendering engine that uses advanced techniques such as dynamic tessellation to render complex landscapes at high frame rates. It can be used in conjunction with PyOSG,
A python module providing a cross-platform and cross-media drawing toolkit. It handles lines, polygons, curves, figures, and text--powerful enough for professional plotting--including support for wxWindows, Tk, Quickdraw, PDF, Postscript, and PIL.