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XMIPP is an image processing suite for 3D-reconstruction of biological specimens from transmission electron microscopy data. NOTE that stable releases (including binaries) are longer stored at Sourceforge, but are available at http://xmipp.cnb.csic.es
AAX Desktop is a suite of desktop applications, utilities, and libraries. It forms a nearly complete desktop environment, including a terminal, clock, calculator, address book, dictionary, lossless image library, etc...
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AGTK is a suite of software components for building tools for annotating linguistic signals,
time-series data which documents any kind of linguistic behavior (e.g. audio, video).
The internal data structures are based on annotation graphs.
A set of games and other applications for the Hoppolek platform, a research project aimed at giving gravely handicapped children a possibility to move and play, while also helping to strengthen their bone structure and normalize their muscle tonus.
matterial is a (free and open source) collection of software for creating art. (With an advanced, shared back-end.) You can think of matterial as an officesuite for artists. But instead of working with office apps, you work with art authoring apps.