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A pipeline to define allele-specific genomic features
Detecting allelic biases from high-throughput sequencing data requires an approach that maximises
sensitivity while minimizing false positives. Here we present Allelome.PRO, an automated userfriendly
bioinformatics pipeline, which uses high-throughput sequencing data from reciprocal crosses
of two genetically distinct mouse strains to detect allele-specific expression and chromatin
modifications. Allelome.PRO extends approaches used in previous studies that exclusively...
Tools to build molecular-docking activity prediction models by PLS regression with iterative training and pose-selection. Descriptors include (i) docking score(s), (ii) pharmacophore features, (iii) multi-feature descriptors learned by decision trees.