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SPiP is a tool to predict the splice alteration of variant by integrate several prediction tool in a global pipeline. You can also download SPiP in zip format: https://sourceforge.net/projects/splicing-prediction-pipeline/files/SPiP_alone_v2_1.zip For Linux (GitHub): https://github.com/LBGC-CFB/SPiP If you have questions, please contact me to: r.leman@baclesse.unicancer.fr or raphael.leman@orange.fr v2.1 corrected (07/2021) : correction of score calculation v2.1 (06/2021): Most strigent on "Alter by complex event" v2.0 (04/2021): New SPiP with random forest modelization old change detailled in https://sourceforge.net/projects/splicing-prediction-pipeline/files/changeLogBeforev2.0.txt

...The details can be found in the original publication "OpenGrowth: an automated and rational algorithm for finding new protein ligands" (J. Med. Chem., http://dx.doi.org/10.1021/acs.jmedchem.5b00886). To use OpenGrowth, you will need OpenGrowth_1.0.zip and Resources_1.0.2.zip that can be found by clicking on the Files menu in the horizontal bar at the top (https://sourceforge.net/projects/opengrowth/files). OpenGrowthGUI, FOG2.0, and the 3Mer-Screen stand-alone can be found in OpenGrowth_1.0.zip. To prepare new fragments you need BuildingFragments_1.0.1.zip and the scripts for MD simulations are in MD-Scripts_1.0.1.zip. ...

...The library includes a graphical user interface to simplify its use. Note that the 2.0-1 version is delivered as a source (*.tar.gz for Linux and Mac users) and as a binary file (*.zip, for Windows users). The installation procedure differs slightly according to your system; but this should remain simple. Have a look at the readme file when you download your new copy from https://sourceforge.net/projects/rawgeno/files/rawgeno/RawGeno%202.0-1/ Make also sure to have a look at https://sourceforge.net/projects/rawgeno/files/ where you can find a detailed manual, demo datasets and many demo scripts.