A real-time software synthesizer based on the SoundFont 2 specifications. It can be used for live audio synthesis of MIDI events or for rendering MIDI files to disk, using SoundFont instruments. It can also be embedded in other applications.
This is not a application with a graphical user interface, however there are several GUI applications which utilize FluidSynth.
Midiball is a simple standalone musical application for Linux to generate midi events from the motion of a virtual ball. It uses Qt and ALSA midi API. It can be also used with the jack daemon.
wtf2osc converts several protocols to OSC (Open Sound Control) and back again and though makes it possible to use them in software like pd, Max or SuperCollider. Currently it supports only DMX and HTTP, expect more to come.
Schnolgo is a multi-format musical composition package written in Python. It is built with an extremely flexible system for representing rhythmic structures and is intended to allow for songs to be written so as to make use of "guided improvisation".
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PJLMidiParser provides efficient parsers, written in Java, for MIDI files. It is like XML SAX parsers in that it is event-driven; the parsing is initiated and then triggers callback handlers in response to events in the MIDI file.