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Structure parameter inference approach for endocrine feedback control
SPINA is software for determining constant structure parameters of endocrine feedback control systems from hormone levels obtained in vivo.
The first version of this cybernetic approach allows for evaluating the functional status of the thyroid gland, i.e. thyroid's secretory capacity (GT or SPINA-GT) and sum activity of peripheral deiodinases (GD or SPINA-GD).
A second version has been developed for insulin-glucose homeostasis. It delivers the secretory capacity of pancreatic beta cells...
SimThyr is a continuous simulation program for the human pituitary-thyroid feedback control system. Applications of this program cover research, including development of hypotheses, and education of students in biology and medicine, nurses and patients.