...VOIs were manually drawn with software Analyze 9,0 (Mayo Clinic) in 18F-DOPA brain image after spatial normalization with a 18F-DOPA Template developed by our group (available at: https://www.nitrc.org/projects/spmtemplates). Each striatum was divided into 6 sub-regions: ventral caudate, anterior dorsal caudate, posterior dorsal caudate, ventral putamen, anterior dorsal putamen and posterior dorsal putamen, based on Mawlawi et al. (J Cereb Blood Flow Metab.2001;21:1034–57) and Oh et al. (J Nucl Med.2012;53:399–406) segmentation. Nonspecific background volume was drawn in the occipital cortex.
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