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Structure parameter inference approach for endocrine feedback control
...It is a class of static function tests that require nothing more than steady-state concentrations of hormones or metabolites obtained in vivo.
The first version of this cybernetic approach had been developed for the evaluation of the functional status of the thyroid gland, i.e. thyroid's secretory capacity (gain of thyroid, GT or SPINA-GT) and sum activity of peripheral deiodinases (GD or SPINA-GD).
A second version has been established for insulin-glucose homeostasis. It delivers the secretory capacity of pancreatic beta cells (SPINA-GBeta), an estimate for the insulin receptor amplification (SPINA-GR) and a static disposition index as a measure for the loop gain of the feedback loop (SPINA-DI).
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...The framework can easily be extended to other model types, e.g. growth/no-growth boundary models. PMM-Lab has been initiated and provided by the Federal Institute for Risk Assessment - BfR (Berlin, Germany). The software is in Beta status. Before using the software you have to read and accept the license and disclaimer (https://sourceforge.net/p/pmmlab/wiki/Disclaimer/). If you do not agree, do not use this software.
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* User defined functions
* Infinite number of variables
* Specific functions for computation of resistors value (E12, E24) rounding, parallel computation, k = 000, M = 000000
* Store the status (hystory of the commands, variables status) between sessions
This software is OPEN SOURCE and released under GPL license so you can feel FREE to use, copy, share, (but above all) to study, analyze and modify it as you like (within the terms of the license).