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The Orbit Determination Toolbox (ODTBX) is developed by the Navigation & Mission Design branch at NASA Goddard Space Flight Center as an advanced mission simulation and analysis tool used for concept exploration, proposal, early design phase, and/or rapid design center environments. ODTBX functions and utilities are combined in a flexible architecture that allows for modular development of navigation algorithms and simulations. The core ODTBX functionality is realized through a set of estimation commands that incorporate Monte Carlo data simulation, linear covariance analysis, and measurement processing at a generic level.