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Python API for Sendmail Milters. Related modules provide features such as content filtering, SPF, and reputation tracking. Changes are posted first to https://github.com/sdgathman/pymilter and related repos.
TMDA is an open source anti-spam system and local mail delivery agent written in 100% pure Python. TMDA combines whitelists, blacklists, a challenge/response system, and special-purpose e-mail addresses called "tagged addresses" to thwart spam.
elspy is an extension to the Exim MTA that allows Exim users to supply a local_scan() function written in Python instead of C. (Exim's local_scan() API lets sysadmins supply site-specific code for approving/rejecting email messages at SMTP time.)
A python wrapper for Local Delivery Agents (for example, maildrop), which allows an unlimited number of extensions on a mail account with dot-qmail-like functionality.