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Genetic variants alter cellular behavior in a variety of ways, changing biochemical properties of DNA, mRNA, and proteins. Many large-scale sequencing projects are under way to detect human variation in health and disease. Although broad disease associations can be discovered by GWAS studies, the low-level impact of mutations is hardly available in structured form. The results of thousands of small-scale experiments, on the other hand, are present in the literature and discuss observations made ranging from alteration of active sites to changes in drug response resulting. ...

Analogical Modeling is an exemplar-based approach to machine learning which imitates human behavior in outcome prediction. Its design has been applied to many natural language and other phenomena which exhibit variable behavior. A Perl XS implementation is available from http://humanities.byu.edu/am/ . This project is a Java implementation of the same. For more information on Analogical Modeling, see http://en.wikipedia.org/wiki/Analogical_modeling .