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Pyro aims to be the first major Roguelike game written in Python. Project goals are clear code, easy modification and extension, and of course, a game that's worth playing. This is an early alpha and not yet winnable.
OpenWWTP is wastewater treatment plant simulator based on (modified) Activated Sludge Model (ASM2d) The project is in very beginning stage (help wanted).
SE|PY is an ActionScript editor written in python, wxPython and using scintilla for text highlight, code collapsing. some features: snippets panel, functions panel and much more.
Contain also Flush
Merovingian is very easy to use but powerful GUI interface for GnuPG. It intends to be well integrated with GNOME, but still usable with other desktop environments too.
PyMOlyze is a graphical program to analyze the results of quantum chemistry (HF/DFT) calculations. Features include various population analyses, fragment analysis, monitoring structures during an optimization, and a simple, but powerful, XYZ editor.
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SIPStir is a bulk call generator for SIP devices/servers. The server piece is capable of generating an infinite variety of call scenarios based on a simple scripting language. A wxPython client can connect to the server to monitor and modify progress.
planimo is an instant messaging system planned for lan chats. It support file transfers between users, can emit beeps whene new message arrive and integrate well in gnome desktop! It works on windows too
The main idea behind tk_happy is to allow a fully "wired" Tkinter application to be quickly created (Tkinter is the python interface to Tk). The users main responsibility is to add logic to the Tkinter framework created by tk_happy.
Gameplay is similar to Bejewelled(tm), but using a hex rather than a square grid for more scoring options. Unique multi-swap moves. Theme-able (with 6 bundled themes). New themes are easy to create and share. Complete manual. Requires Python and Pygame.
This is a go game SGF editor and go playing program. It will be able to play on IGS as a client and KGS as a bot. It will use GNUGo any other GTP protocol program for it's computer go capabilities. It uses sgflib.py for SGF Parsing.
Massively Multi-Threaded and fully Object-Oriented game engine. An easily extensible core library, along with embedded Python for easy scripting of just about anything, makes the Auross engine a perfect choice for just about any gaming project.
SDB is an utility for traders to manage a collection of live shows. It currently features various export formats (txt, html, php, xml) and a gui to browse, add, edit your shows.
The Markovski project implements an interpreter/compiler for a language named Markovski, used to write Markov algorithms (see http://en.wikipedia.org/wiki/Markov_algorithm).