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a mass spectrometry–based proteomics database search algorithm
...We have discovered that for high-resolution MS/MS, simple spectrum preprocessing and scoring performs superior to more complex algorithms originally developed for low-resolution MS/MS, such as Sequest, Mascot, and OMSSA. Morpheus is also very fast—up to nearly 5 times faster than OMSSA for large human datasets. It is written in C# and is available open source under the permissive MIT License.
Label-free Quantitative Analysis Tool for LC-MS/MS Proteomics Data
LFQuant is a new analysis tool for label-free LC-MS/MS quantitative proteomics data. It is compatible with high-resolution mass spectrometers (Thermo RAW data) and two popular database search engines (SEQUEST and MASCOT) with target-decoy search strategy.
LFQuant is written in Microsoft Visual C++ 2005 and runs on any Windows system. This software and any associated documentation are provided “as is” and there is no warranty for this software.