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ddreditor (Digital Didatic Resource Editor) is a editor of Digital Didatic Resources (learning objects and more). It is implemented using Python and it´s GTK bindings and uses a docbook substed as it´s markup language.
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Orange 3D, a game engine distributed under the zlib/libpng license, is an all in one solution, with IDE, level editor, 2d painter, 3d modeler, and possibly audio editing software all in one clean package, for free!
Python-based GUI for discrete-event system modeling and simulation
DEVSimPy is an advanced wxPython GUI for the modeling and simulation of systems based on the DEVS (Discrete EVent system Specification) formalism. Features include powerful built-in editor, advanced modeling approach, powerful discrete event simulation algorithm, import/export DEVS components library and more.
DXIE is a Dynamic XML Instance Editor that provides dynamic GUI editing of XML documents. DXIE reads a Document (XML) and its Schema (XSD) and produces a dynamic UI for editing (search, add, edit, and delete) of the Document.
RGnome is a gtk based frontend for GNU R, which is a widely used language for statistical computing. It features a fully working R console and an editor with syntax highlighting.