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AquaTerm is a Mac OS X grahics renderer. It allows command line applications written in ObjC, C, FORTRAN, Lisp, Perl or Python to display vector graphics, text and images using a simple API. Adapters for gnuplot, PGPLOT, and PLplot exists as well.336 weekly downloads
The AbiWord word processor is a full-featured cross-platform word processor.70 weekly downloads
The Mac TeX Toolbox provides an umbrella for TeX related development for Mac OS X: discussions, pointers to libraries and other support for open source TeX development on Mac OS X.6 weekly downloads
The Open Descent Foundation (ODF) is a community for developers, who want to help to create open source programs, tools, etc. for the famous games Descent1, -2 or -3. Everyone can join the ODF if he accepts the idea of writing open source programs.
The Gnuritas project aims at designing a "smart" and flexible framework and tools to manage and share knowledge, information and scientific data.