(Historical) PyAcad makes Python available as a scripting language to AutoCAD/IntelliCAD. A builtin module "ads" allows to access and control most aspects of AutoCAD/IntelliCAD from Python programs.
wxStudio is an attempt to make an IDE and code generation tool using the wxWindows GUI toolkit.
Team Insanitea will be developing the Insanitea role playing game engine.
This project will create python plugins for the common corporate directory services, NDS, ActiveDirectory and LDAP. These modules are targeted at system administration staff and python developers.
TeXPerfect plans to be a cross-platform, extensible, user-friendly yet expert-tunable visual TeX implementation. The most important feature will be a split screen (inspired by WordPerfect(R) Reveal Codes) showing the underlying TeX code.