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Pyjamas is a python to Javascript compiler, Widget set, Framework and Toolkit for Application development that runs on Web browsers. The developer need not know anything about AJAX: all the AJAX tricks, for all major browsers, are entirely taken care of.
Pyjamas-Desktop is the Desktop version of the Pyjamas Web Widget toolkit. Pyjamas-Desktop can even execute javascript, and embed plugins such as Flash. Pyjamas-Desktop is now part of http://pyjs.org