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Pierce is an open source event based framework for building IRC bots (or potentially clients?). It is written in Python and contains default handlers as well as some extra handlers that make bot creation simple.
The purpose of this project is to create a very extensible irc client (and accompanying server) by building it out of independent and replacable (two species of the same kind of object can exist) COM objects.
mIkro IRC Bot is a complete bot framework written in C#. That means that you can write your own irc bot simply using C#, set up and start them dinamically. The bot building and connection processes are managed by a Windows Service.