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Nested commands, easy configuration, and an incredibly flexible and easy-to-use plugin system distinguish Supybot from other IRC bots. There simply isn't a more flexible or easier to use IRC bot!
General and simple IRC bot framework with very flexible bus architecture and plugins support, originally written for use as RPC gateway for remote message sending to multiple IRC channels or users. Now: http://github.com/martinkozak/pyircgate-daemon.
Madcow is an extensible IRC/SILC/AIM bot written in Python. It is fully customizable and has a simple API for creating modules that extend its functionality. This project has moved to: http://code.google.com/p/madcow/
Ennesbot is an open source automated IRC client (aka Bot) written entirely in Python. It uses direct sockets and medusa style sockets. It has pluggable python personality modules that can extend the bot.
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Muffinbot is an IRC bot that makes having a bot easy. Muffinbot is simple to install, run, configure, and make work for your purposes. The source and plugins are written in PHP. Muffinbot is configured through either the web or the command line.
ScriptBot is a scriptable IRC bot. Based on PircBot and BSF, it allows to fully customize the bot's behaviour by editing script files in the scripting language of your choice.
Clogger is an IRC bot that logs IRC conversations that will be abled to be searched and displayed in a channel upon user request. The bot's search engine efficiently searches what it logs and outputs it's results to the user in the channel.
Pynfo is an IRC bot written in Python and the Twisted framework. Among its features are network bridging/relaying, basic "infobot" capabilities, googling, 3 access tiers, and a shorter-link function. Pynfo is easily extensible and fully disk-persisten
Full featured, modular IRC bot built from scratch in Python, similar to eggdrop. The internal object oriented IRC library is designed to be both flexible and extensible and is easily separated from the rest of the bot for other projects.
PjBOT is a fun-oriented irc bot. It does trivial (making statistics of the results, creating a webpage) and in the near future more games.
It is developed in Python. It's Multiplatform and GPL.
PyOP (Python Optimus Prime bot) is an Open Source IRC bot written in Python. It's intended to be simple, fast and modular.
Support for jabber/MSN is planned.
AoCBot is a pythonbot that wraps together IRC and the Age of Conan chatserver. It has some helpful AoC-related features like whois/IRC relay, and offers a very easy way to add your own plugins.