Virmid
Virtual Microdissection for SNP calling
...Virmid is also specialized for identifying potential within individual contamination where the disease sample cannot be purified enough. While the SNP calling rate is severely compromised with this heterogeneity, Virmid can uncover SNPs with low allele frequency by considering the level of contamination (alpha). The important features of Virmid are:
•Estimation of accurate proporation of control sample in a (mixed) disease sample
•Improved SNP and somatic mutation calling with regard to the estimated proportion