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...It is built on top of the Insight Segmentation and Registration Toolkit ITK with the intent of providing a simplified interface to ITK. SimpleITK itself is written in C++ but is available for a large number of programming languages. Wrapping of the C++ code is accomplished through SWIG, in principle, any language wrapped by SWIG should be applicable to SimpleITK. Unlike ITK's support of n-dimensional spatio-temporal images, SimpleITK supports 2D, 3D and 4D images. The dimensionality refers to spatiotemporal dimensions, the voxels can be n-dimensional vectors. Open-source multi-dimensional image analysis in Python, R, Java, C#, Lua, Ruby, TCL and C++. ...