PTM is a Perl/HTML hybrid, similar to PHP in tag syntax. It allows for the ease of PHP-style inline code in your dynamic HTML documents while supplying the power of Perl that many find to be sorely lacking in PHP.
Reptile is a web server made in Python. It supports server side scripting with "Embedded Python", PHP, and CGI scripts.
It has an integrated HTML/XML validator that checks the pages before publication and others handy features.