OpenRTS is an open source realtime strategy game. It features isometricgraphics, networked multiplayer and single-player scenarios. The game is being developed using Python and SDL. The game runs on at least Linux, Windows and Mac.
PySometric is an Isometric RPG written in Python. It uses PyGame for graphics, and will feature online play through a peer to peer network. Most of the programmers are learning how to program a 2-d game, and all new programmers are welcome.