Diggo a 2D version of minecraft made with Pygame!
Develop an emulated Darkfall Online Server.
A ridiculously simple spaceship shoot 'em up game written in Python
A text-based adaptation of the classic tabletop game 'Pass the Pigs'
CometZ is a simple side scrolling space shooter
Super Mario Python Final
Python/Pygame Game-Building Framework
A Space Master 2nd Edition Character Generator
A 2D Elite-style game written in Python 3.2.
Tactical, turn-based game engine, that uses OpenGL and WinAPI
Open source, moddable game engine for the "Polygon Love 2" game
Open Source Virtual World and MMOG Development Platform
Conway's Game of Life and Turmites Combined!
6DOF zero-g claustrophobic space shooter
Python Killboard Platform for EVE Online
Scriptable GTK based Python MUD Client
Invaders like game, written in Python with Curses... :)