The Ren'Py Visual Novel Engine
A game engine powered by python and panda3d
A retro game engine for Python
Open source clone of the Age of Empires II engine
3D game engine/framework in C, with Luajit and Python bindings now
Powerful, mature open-source cross-platform game engine for Python
Python MUD/MUX/MUSH/MU* development system
An OpenGL RTS game engine written in C
Pycraft is an open-source, OpenGL based game made in Python
Free, open source game engine online
scene-oriented, flexible 3D engine (C++, Python, C#, Java)
GemRB is a portable open-source implementation of the Infinity Engine
Royal Entertainment Graphics eXecution (REX)
Vivid3D is a C++ IDE/3D engine, with python scripting.
PyCAPGE - Python Classic Adventure Point and Click Game Engine
A cell-based puzzle game featuring classic and completely new puzzles
A game engine for console based text games
Python ctypes module for the Irrlicht Engine SDK
DOOM / Heretic / Hexen source port with enhanced graphics and UI
KlayGE is a cross-platform open source game engine
The second demo of my game engine.