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The TuxCap Games Framework is a GNU/Linux and Mac OSX port of the PopCap Games Framework used for 2D game development. It comes with PyCap Python bindings, a fast 2D physics engine, a particle engine, widgets and many documented examples.
Cross platform 2D game creation framework with Python bindings
FIFE is a cross platform 2D game creation framework written in C++ with Python bindings. It's designed to be flexible enough to support a wide variety of 2D game types but specializes in 2D isometric type views.
Pyzzle is a cross-platform game engine for creating large-scale, 2D Myst-like adventure games. The engine supports 2D panoramas, features an intuitive design mode, and allows users to download content from the internet. Pyzzle is written using Pygame.
The main purpose of the Moonlight Engine is to be a general 2D game engine geared towards tile-based games, and RPGs specifically. Support for online games is also planned.
NiL is a modular multi-purpose gaming engine including a multiplayer worm game a little like quake, except it's 2d and a little like worms except it's realtime.